Monday, March 23, 2009

Blocked Enzyme Reverses Schizophrenia-like Symptoms


I think that Schizophrenia is a very bad disease, that worries me how you get it. My family friend was recently diagnosed with it, and had to quit being a police. Rest his soul. Schizophrenia is no joke. Researchers at MIT's Picower Institute for Learning and Memory have found that inhibiting a key brain enzyme in mice reversed schizophrenia-like symptoms.The finding, reported in the March 20 issue of Cell, identified how a particular gene controls this brain enzyme. Better understanding of the relationship could lead to new drug treatments for schizophrenia, the severe brain disorder that affects about 1 percent of the population and is characterized by hallucinations, delusions, poor social and emotional functioning and disorganized thoughts.

The Picower research focused on a gene known as DISC1 (short for "disrupted in schizophrenia 1"), which was first identified in the 1990s by researchers studying the genetic makeup of a large Scottish family with mental and behavioral disorders. DISC1 has since been shown to help brain neuronal cells migrate to their correct positions and to help new neurons grow in the developing brain, but its role was not well understood.

Original Article
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